SML1669

NCX 4016

≥98% (HPLC)

• Synonym(s): 2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, NCX-4016, Nitroaspirin
• Empirical Formula (Hill Notation): C₁₆H₁₃NO₇
• CAS Number: 175033-36-0
• Molecular Weight: 331.28
• NACRES: NA.77
• PubChem Substance ID: 329826004
• UNSPSC Code: 51111800
• MDL number: MFCD01939436
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(OC1=CC=CC=C1C(OC2=CC(CO[N+]([O-])=O)=CC=C2)=O)=O
• InChI: 1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
• InChI key: IOJUJUOXKXMJNF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

NCX 4016 (nitroaspirin) is nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor. NCX 4016 improves postischemic ventricular dysfunction and to reduce myocardial infarct size in rabbit.

Nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor

NCX-4016 can prevent the progression of cisplatin-resistant human ovarian cancer xenografts in mice. It can also regulate the expression of B-cell lymphoma 2 (Bcl-2) proteins in ovarian cancer cells. Hence, NCX-4016 is considered a promising therapeutic option against carcinoma.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable