SML0954

Thiocolchicine

≥97% (HPLC)

• Synonym(s): 10-Demethoxy-10-(methylthio)colchicine, 10-Thio-colchicine, N-[(7S)-5,6,7,9-Tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide, NSC 186301
• Empirical Formula (Hill Notation): C₂₂H₂₅NO₅S
• CAS Number: 2730-71-4
• Molecular Weight: 415.50
• UNSPSC Code: 12352200
• EC Number: 220-346-8
• NACRES: NA.77
• Assay: ≥97% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: S(C)c1[c](cc2c(cc1)c3c(cc(c(c3OC)OC)OC)CC[C@@H]2NC(=O)C)=O
• InChI: 1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
• InChI key: CMEGANPVAXDBPL-INIZCTEOSA-N

Description

Biochem/physiol Actions

Thiocolchicine is an antimitotic alkaloid and apoptosis inducer that inhibits tubulin polymerization and microtubule assembly.

Thiocolchicine is an antimitotic alkaloid and apoptosis inducer.

Safety Information

• Pictograms: GHS06,GHS08,GHS05
• Signal Word: Danger
• Hazard Codes: H300 + H330,H318,H340
• Precautionary Statements: P202 - P260 - P264 - P280 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Muta. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable