SML0313

Pimelic Diphenylamide 106

≥98% (HPLC)

• Synonym(s): Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106
• Empirical Formula (Hill Notation): C₂₀H₂₅N₃O₂
• CAS Number: 937039-45-7
• Molecular Weight: 339.43
• NACRES: NA.77
• PubChem Substance ID: 329825318
• UNSPSC Code: 12352200
• MDL number: MFCD17010287
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
• InChI: 1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
• InChI key: WTKBRPXPNAKVEQ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.

106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.

Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable