Skip to Content
Merck
All Photos(1)

Key Documents

SCP0093

Sigma-Aldrich

Caspase Inhibitor

≥95% (HPLC)

Synonym(s):

Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C21H34N4O10
Molecular Weight:
502.52
UNSPSC Code:
12352200
NACRES:
NA.32

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Gene Information

Amino Acid Sequence

Ac-Leu-Glu-Thr-Asp-al

Application

Caspase inhibitor Ac-LETD-CHO has been used to inhibit caspase-8.

Biochem/physiol Actions

The peptide Ac-Leu-Glu-Thr-Asp-al, or Ac-LETD-CHO, is a known caspase inhibitor. Ac-LETD-CHO has been reported to exert inhibitory effects on caspase 8 and on caspase 9.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jie Shi et al.
Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been
Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells
Hashimoto, T., et al.
ACS Symp. Ser., 851, 128-140 (2003)
Sei-Jung Lee et al.
The Journal of nutritional biochemistry, 19(3), 166-174 (2007-06-26)
This study was carried out to investigate the apoptotic effects of glycine- and proline-rich glycoprotein [Solanum nigrum Linne (SNL) glycoprotein, 150-kDa] isolated from SNL, which has been used as an antipyretic and anticancer agent in Korean herbal medicine. We found
Takashi Araki et al.
Nephron. Experimental nephrology, 93(3), e117-e124 (2003-03-28)
Programmed cell death is a mechanism by which organisms dispose of unwanted cells, and it is thought to be an important process in organogenesis. We have already reported the role of caspase-3 in the developing metanephros. While caspase-3 is thought
Apoptotic Regulation of Caspase Activity
Martinova, E.A., et al.
Russian J. Bioorg. Chem., 29, 471-495 (2003)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service