RAB0026
Human BDNF ELISA Kit
for serum, plasma, cell culture supernatant and urine
Synonym(s):
BDNF, Brain-derived neurotrophic factor
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All Photos(2)
About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
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species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type plasma
sample type serum
sample type cell culture supernatant(s)
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 80 pg/mL
standard curve range: 0.066-16 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BDNF(627)
General description
The Human BDNF ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BDNF in serum, plasma, cell culture supernatants and urine.
The brain derived neurotrophic factor (BDNF) gene is mapped to human chromosome 11p14.1. BDNF is a member of the neurotrophin family of growth factors. The gene encodes a precursor protein, proBDNF. Mature BDNF (mBDNF) is synthesized by post-translational cleavage of proBDNF. Both proBDNF and mBDNF play crucial roles in cellular signaling.
Immunogen
Recombinant Human BDNF
Application
For research use only. Not for use in diagnostic procedures.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA kit has been used to determine the effect of bone marrow mesenchymal stem cell (MSC) transplantation on BDNF protein expression in the striatum of Tourette syndrome (TS) rats. It has also been used to determine the plasma BDNF levels in GD1 (Gaucher′s disease type 1) patients and control population.
Human BDNF ELISA Kit has been used:
- to measure the brain-derived neurotrophic factor (BDNF) protein expression
- to determine BDNF level in the slice culture medium and the extracts of organotypic brain slice cultures (OBSCs)
- to determine BDNF level in plasma
Biochem/physiol Actions
Brain derived neurotrophic factor (BDNF) is involved in hippocampal function and verbal episodic memory in humans. Hence, variation in the BDNF gene expression alters these neurological functions. BDNF also plays a vital role in vascular function and participates in angiogenesis via the specific receptor tropomyosin-related kinase B (TrkB). It is involved in the pathogenesis of Alzheimer′s disease. ProBDNF interacts with p75 neurotrophin receptor, leading to long-term depression in the hippocampus.
Other Notes
A sample Certificate of Analysis is available for this product.
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Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
Certificates of Analysis (COA)
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Customers Also Viewed
Xiumei Liu et al.
Experimental and therapeutic medicine, 11(4), 1211-1216 (2016-04-14)
The aim of the present study was to investigate the effect of bone marrow mesenchymal stem cell (MSC) transplantation on brain-derived neurotrophic factor (BDNF) expression in the striatum of Tourette syndrome (TS) rats. In addition, the possible mechanism of MSC
Hélio José Coelho-Júnior et al.
International journal of environmental research and public health, 17(10) (2020-05-20)
The present study compared the effects of traditional resistance training (TRT) and combined power training (PT) and TRT (PTRT) on cognitive parameters and serum brain-derived neurotrophic factor (BDNF) levels in non-demented, well-functioning, community-dwelling older women. Forty-five older women were randomized
Zuzana Paduchová et al.
Nutrients, 13(4) (2021-04-04)
In the DEPOXIN project, we have found that a high ratio of omega-6/omega-3 fatty acids (FA) is associated with worsening of depressive symptoms in children and adolescents with depressive disorder (DD) and that the 12-week omega-3 FA supplementation modulates DD
Alexandre Silva de Mello et al.
Clinical biochemistry, 50(4-5), 228-233 (2016-11-21)
Gaucher's disease type 1 (GD1) pathophysiology includes an imbalance on brain-derived neurotrophic factor (BDNF) levels and in the inflammatory system. However, the pathways involved remain poorly understood. The hypothesis of this study is that epigenetic mechanisms might be involved, at
Running-induced functional mobility improvement in the elderly males is driven by enhanced plasma BDNF levels and the modulation of global histone H4 acetylation status
Figueiredo AI, et al.
Middle East Journal of Rehabilitation and Health Studies, 4(3) (2017)
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