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H7891

Sigma-Aldrich

Hexammine cobalt(III) chloride

for use in transformations, X-ray crystallography and NMR

Synonym(s):

Cobalt hexammine trichloride, Hexaamminecobalt trichloride

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About This Item

Linear Formula:
[Co(NH3)6]Cl3
CAS Number:
Molecular Weight:
267.48
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.52

grade

for molecular biology

Quality Level

form

powder

storage temp.

room temp

SMILES string

N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Co+3]

InChI

1S/3ClH.Co.6H3N/h3*1H;;6*1H3/q;;;+3;;;;;;/p-3

InChI key

JXBGZYGSWFSYFI-UHFFFAOYSA-K

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General description

Hexammine cobalt(III) is considered an analog of fully solvated magnesium, capable of activating some enzymes that requires magnesium. It is useful in DNA condensation studies.

Application

Suitable for
  • DNA condensation studies
  • induction of transitions of DNA from B to A or Z forms
  • induction of nucleic acid crystal growth
  • stabilization of tertiary tRNA interactions
  • preparation of ligation buffer

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Aquatic Chronic 4 - Carc. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Filip Senigl et al.
Cell reports, 29(12), 3902-3915 (2019-12-19)
Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome. We have used lentiviral SHM reporter vectors to identify regions of the genome that are susceptible ("hot") and resistant ("cold")
HCC ligation: rapid and specific DNA construction with blunt ended DNA fragments.
J A Murray
Nucleic acids research, 14(24), 10118-10118 (1986-12-22)
B Grünewald
The Journal of comparative neurology, 404(1), 114-126 (1999-01-14)
The anatomy of gamma-aminobutyric acid (GABA)-immunoreactive, recurrent feedback neurons in the mushroom body (MB) of the honeybee, Apis mellifera, was investigated by using intraneuropilar injections of cobalt ions and light microscopic techniques. Each MB contains approximately 110 GABA-immunoreactive neurons, and
Y Tsubamoto et al.
The Journal of biological chemistry, 276(5), 2979-2985 (2000-11-09)
Hexamminecobalt(III) (HAC) chloride was found to have a potent inhibitory effect on glucose-induced insulin secretion from pancreatic islets. HAC at 2 mm inhibited the secretion in response to 22.2 mm glucose by 90% in mouse islets. Perifusion experiments revealed that
Dynamic nature of B to Z transition: role of DNA supercoiling and Z-DNA binding protein.
N Ramesh et al.
Indian journal of biochemistry & biophysics, 25(6), 542-547 (1988-12-01)

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