H139

HA-1077 dihydrochloride

solid, ≥98% (HPLC)

• Synonym(s): 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
• Empirical Formula (Hill Notation): C₁₄H₁₇N₃O₂S · 2HCl
• CAS Number: 203911-27-7
• Molecular Weight: 364.29
• MDL number: MFCD00153805
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895456
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: H₂O: >10 mg/mL
• SMILES string: Cl[H].Cl[H].O=S(=O)(N1CCCNCC1)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• InChI key: NOXXIYDYFSNHDF-UHFFFAOYSA-N

Description

Application

HA-1077 dihydrochloride has been used:

• to relax cantilevers
• in the functional assessment of isolated coronary arteries
• to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Biochem/physiol Actions

HA-1077/fasudil, is a Rho kinase inhibitor. This ROCK inhibitor has the ability to increase cognitive deficits in animals, that have Alzheimer′s disease (AD). In humans, fasudil possesses high therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH). HA-1077 also acts as an inhibitor of protein kinases, like myosin light chain kinase and Rho associated kinase. Hence, it can block myosin phosphorylation.

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca²⁺ antagonist.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves