E3145

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene

≥90%

• Synonym(s): NOC-12
• Empirical Formula (Hill Notation): C₆H₁₆N₄O₂
• CAS Number: 146724-89-2
• Molecular Weight: 176.22
• MDL number: MFCD00674898
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799041
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥90%
• storage temp.: −20°C
• SMILES string: CCNCCN(CC)\[N+]([O-])=N\O
• InChI: 1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
• InChI key: DPKCLDSTXVCYSN-NTMALXAHSA-N

Description

General description

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) is a donor of nitric oxide (NO). It has a long half-life of 327 minutes.

Application

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as nitric oxide (NO) donor to study its effects on the isolated trachea preparations from control and ovalbumin-sensitized guinea pigs in vitro. It has also been used as a NO-releasing substance to study its effects on the body contractions patterns of Tethya wilhelma.

Biochem/physiol Actions

3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) liberates nitric oxide (NO) without the use of cofactors or enzymes and the formation of hazardous metabolites. A low dose of NOC12 protects astrocytes from reperfusion injury via a cyclic guanosine monophosphate (cGMP) signal. Higher dosages of NOC12 aggravates reperfusion damage through a cyclic guanosine monophosphate (cGMP)-independent mechanism.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H242
• Precautionary Statements: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves