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Bovine Collagen Type II

Name: Bovine Collagen Type II
Brand: SIGMA

from bovine tracheal cartilage, powder

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About This Item

CAS Number:

9007-34-5

UNSPSC Code:

12352202

NACRES:

NA.61

EC Number:

232-697-4

MDL number:

MFCD00130825

Form:

powder

Biological source:

bovine cartilage (tracheal)

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Properties

Product Name

Collagen from bovine tracheal cartilage, Bornstein and Traub Type II, powder

biological source

bovine cartilage (tracheal)

Quality Segment

200

form

powder

solubility

aqueous acid: soluble

UniProt accession no.

P02459

storage temp.

2-8°C

Gene Information

cow ... COL2A1(407142)

Description

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).

Application

Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).

Biochem/physiol Actions

Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

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This Item	C9879	C9791	C2124
Sigma-Aldrich C1188 Collagen from bovine tracheal cartilage	Sigma-Aldrich C9879 Collagen from bovine achilles tendon	Sigma-Aldrich C9791 Collagen from calf skin	Sigma-Aldrich C2124 Collagen solution from bovine skin
description Bornstein and Traub Type II, powder	description powder, suitable for substrate for collagenase	description Bornstein and Traub Type I, solid, BioReagent, suitable for cell culture	description 6 mg/mL, sterile-filtered, (suitable for cell culture and for 3D matrix formation), BioReagent
biological source bovine cartilage (tracheal)	biological source bovine Achilles tendon	biological source bovine (calf) skin	biological source bovine skin
form powder	form powder	form solid	form liquid
solubility aqueous acid: soluble	solubility -	solubility 0.1 M acetic acid: 1 mg/mL (Allow to stir at room temperature 1-3 hours until dissolved.)	solubility -
UniProt accession no. P02459	UniProt accession no. P02459	UniProt accession no. P02453	UniProt accession no. -
Gene Information cow ... COL2A1(407142)	Gene Information -	Gene Information bovine ... COL1A1(282187)	Gene Information -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C