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Aprotinin from bovine lung

Name: Aprotinin from bovine lung
Brand: SIGMA

lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

Synonym(s):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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About This Item

Empirical Formula (Hill Notation):

C₂₈₄H₄₃₂N₈₄O₇₉S₇

CAS Number:

9087-70-1

Molecular Weight:

6511.44

UNSPSC Code:

12352202

NACRES:

NA.26

EC Number:

232-994-9

MDL number:

MFCD00130541

eCl@ss:

32190102

Form:

crystalline (fine)

Assay:

~80% (HPCE)

Biological source:

bovine lung

Mol wt:

~6,500

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Properties

biological source

bovine lung

Quality Segment

200

assay

~80% (HPCE)

form

crystalline (fine)

quality

lyophilized

specific activity

≥3500 U/mg

mol wt

~6,500

technique(s)

electrophoresis: suitable

color

white

input

mammalian sample(s)

solubility

phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))

UniProt accession no.

P00974

storage temp.

2-8°C

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Gene Information

cow ... PTI(404172)

Description

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Other Notes

1 U corresponds to 1 biological kallikrein inhibitor unit (KIU)

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

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This Item	A6106	A3428	A1153
Sigma-Aldrich 10820 Aprotinin from bovine lung	Sigma-Aldrich A6106 Aprotinin from bovine lung	Sigma-Aldrich A3428 Aprotinin from bovine lung	Sigma-Aldrich A1153 Aprotinin from bovine lung
description lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg	description BioUltra, 3-8 TIU/mg solid, ≥98% (SDS-PAGE)	description lyophilized powder, 3-8 TIU/mg solid, BioReagent, suitable for cell culture	description lyophilized powder, 3-8 TIU/mg solid
assay ~80% (HPCE)	assay ≥98% (SDS-PAGE)	assay -	assay -
technique(s) electrophoresis: suitable	technique(s) inhibition assay: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -
biological source bovine lung	biological source bovine lung	biological source bovine lung	biological source bovine lung
mol wt ~6,500	mol wt ~6,500	mol wt ~6,500	mol wt ~6,500
form crystalline (fine)	form powder	form lyophilized powder	form lyophilized powder
UniProt accession no. P00974	UniProt accession no. P00974	UniProt accession no. P00974	UniProt accession no. P00974

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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