BP787

Colecalciferol

British Pharmacopoeia (BP) Reference Standard

• Synonym(s): Cholecalciferol, (+)-Vitamin D₃, 7-Dehydrocholesterol activated, Activated 7-dehydrocholesterol, Calciol
• Empirical Formula (Hill Notation): C₂₇H₄₄O
• CAS Number: 67-97-0
• Molecular Weight: 384.64
• EC Number: 200-673-2
• UNSPSC Code: 41116107
• NACRES: NA.24
• Beilstein/REAXYS Number: 2339331
• MDL number: MFCD00078131
• eCl@ss: 34058003

Properties

• grade: pharmaceutical primary standard
• API family: cholecalciferol
• form: crystalline
• shelf life: limited shelf life, expiry date on the label
• manufacturer/tradename: BP
• color: white
• mp: 83-86 °C (lit.)
• application(s): pharmaceutical; pharmaceutical small molecule
• format: neat
• storage temp.: −20°C
• SMILES string: CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
• InChI key: QYSXJUFSXHHAJI-YRZJJWOYSA-N
• Gene Information: human ... VDR(7421)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Colecalciferol is a fat soluble vitamin, which participates in the calcium and phosphate metabolism. It is sourced either through the diet or by exposing skin to ultraviolet rays. Oral administration of vitamin D₃ is readily absorbed and is stored in adipose tissue.

Application

Colecalciferol BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:

Alendronic Acid and Colecalciferol Tablets

Colecalciferol Injection

Paediatric Vitamins A, C and D Oral Drops

Colecalciferol Tablets

Calcium and Colecalciferol Chewable Tablets

Calcium and Ergocalciferol Tablets

Calcium and Ergocalciferol Chewable Tablets

Ergocalciferol Tablets

Calcium and Colecalciferol Tablets

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Vitamin D acts through a receptor that modulates the proliferation and differentiation of both normal and cancer cells.

Packaging

Unit quantity: 500 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Codes: H300 + H310 + H330,H372
• Precautionary Statements: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - STOT RE 1 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable