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MAB1820

Sigma-Aldrich

Anti-Scribble Antibody

clone 7C6.D10, Chemicon®, from mouse

Synonym(s):

Scrib, LAP4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

purified antibody

antibody product type

primary antibodies

clone

7C6.D10, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

isotype

IgG1κ

GenBank accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SCRIB(23513)

General description

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Specificity

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Immunogen

Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Application

Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers

Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Quality

Routinely evaluated by Western blot on HeLa cell lysates.

Target description

220 kDa

Physical form

Format: Purified
Purified in PBS containing with 0.05% NaN3.

Storage and Stability

Maintain at 2-8°C for up to 1 year after date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum
Sang Joon Won et al.
ACS chemical biology, 13(6), 1560-1568 (2018-05-08)
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity proteins, and G proteins as rapidly cycling S-palmitoylated proteins sensitive

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