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For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
8.22339
Phosphoryl chloride
for synthesis
Synonym(s):
Phosphoryl chloride, Phosphorus oxide trichloride, Phosphorus oxychloride
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About This Item
grade
synthesis grade
Quality Segment
vapor pressure
36 hPa ( 20 °C)
assay
≥99.0% (argenometric)
form
liquid
potency
36 mg/kg LD50, oral (Rat)
reaction suitability
reaction type: Halogenations
dilution
(for synthesis)
pH
1.0 (25 °C, 5 g/L in H2O)
bp
105.3 °C/1013 hPa
mp
1-2 °C
density
1.68 g/cm3 at 20 °C (DIN 51757)
storage temp.
2-30°C
SMILES string
[P](=O)(Cl)(Cl)Cl
InChI
1S/Cl3OP/c1-5(2,3)4
InChI key
XHXFXVLFKHQFAL-UHFFFAOYSA-N
General description
Application
- A phosphorylating agent for the selective phosphorylation of alcohols, amines, and thiols.
- A dehydrating agent for alcohols, amides, and cyanohydrins.
- A reagent to synthesize Vilsmeier reagent for Vilsmeier-Haack formylation reactions.
- A chlorinating agent for the chlorination of heterocyclic compounds.
- A reagent to prepare dihydroisoquinolines and isoquinolines by cyclization of N-β-phenylethyl amides via Bischler-Napieralski reaction.
Analysis Note
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - STOT RE 1 Inhalation
Target Organs
Respiratory Tract
supp_hazards
Storage Class
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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