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Carboxy-PTIO Sodium Salt

Name: Carboxy-PTIO Sodium Salt
Brand: MM

≥97% (TLC), Nitric oxide scavenger, solid

Synonym(s):

Carboxy-PTIO, Sodium Salt, 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, Na

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₆N₂O₄ · Na

Molecular Weight:

299.28

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Product Name

Carboxy-PTIO, Sodium Salt, Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.

Quality Segment

100

assay

≥97% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

dark blue

solubility

HEPES Buffer: 0.4 mg/mL

shipped in

ambient

storage temp.

−20°C

Description

General description

Reacts with nitric oxide at pH 7.4, resulting in the generation of NO₂^-/NO₃^- with a rate constant of 1 x 10⁴ M^-1sec^-1. Prevents SIN-1 induced endothelial cell death. Reported to have potent therapeutic value in endotoxin shock through its nitric oxide scavenging action.

Biochem/physiol Actions

Reversible: no

Cell permeable: no

Primary Target
Nitric oxide scavenging action

Product does not compete with ATP.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 1 week at 4°C.

Other Notes

Ishii, M., et al., 1999. J. Cardiovasc. Pharmacol. 33, 295.
Amano, F., and Nova, J. 1995. FEBS Lett.368, 425.
Hogg, N., et al. 1995. Free Radical Res.22, 47.
Az-ma, T., et al. 1994. Life Sci.54, 185.
Yoshida, M., et al. 1994. Biochem. Biophys. Res. Commun.202, 923.
Akaike, T., et al. 1993. Biochemistry32, 827.
Yoshida, K., et al. 1993. Infect. Immun.61, 3552.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	523350	C221	P5084
Sigma-Aldrich 217386 Carboxy-PTIO, Sodium Salt	Sigma-Aldrich 523350 PTIO	Sigma-Aldrich C221 Carboxy-PTIO potassium salt	Sigma-Aldrich P5084 PTIO
description Reacts with nitric oxide at pH 7.4, resulting in the generation of NO2⁻/NO3⁻ with a rate constant of 1 x 10⁴ M⁻¹sec⁻¹.	description Nitric oxide radical scavenger.	description -	description -
form solid	form solid	form powder	form powder
assay ≥97% (TLC)	assay ≥98% (titration)	assay ≥98% (TLC)	assay -
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition desiccated (hygroscopic), protect from light, OK to freeze	storage condition OK to freeze	storage condition -	storage condition -

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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