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E-022

Supelco

EDDP perchlorate solution

1.0 mg/mL in methanol (as pyrolinium), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

Methadone metabolite

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About This Item

Empirical Formula (Hill Notation):
C20H24ClNO4
CAS Number:
31161-17-8
Molecular Weight:
377.86
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as pyrolinium)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

C[N+]1=C(CC)C(C2=CC=CC=C2)(C3=CC=CC=C3)CC1C.O=Cl(=O)([O-])=O

InChI

1S/C20H24N.ClHO4/c1-4-19-20(15-16(2)21(19)3,17-11-7-5-8-12-17)18-13-9-6-10-14-18;2-1(3,4)5/h5-14,16H,4,15H2,1-3H3;(H,2,3,4,5)/q+1;/p-1

InChI key

FICCBMGBBWWZRF-UHFFFAOYSA-M

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General description

A certified Snap-N-Spike® solution of the major urinary metabolite of methadone. Methadone, sold under various trade names such as Symoron, Amidone or Methadose®, is a synthetic opioid used medically as an analgesic and as a maintenance anti-addictive for use in patients with opioid dependency. Suitable uses for this reference standard include as starting material in preparation of calibrators and controls for LC/MS or GC/MS methods in methadone testing for applications in clinical toxicology or forensic analysis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Methadose is a registered trademark of Mallinckrodt Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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M-007

(±)-Methadone solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

E-006

EDDP perchlorate, ampule of 10 mg, certified reference material, Cerilliant®

E-021

EDDP-D3 perchlorate solution, 100 μg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

E-057

EMDP hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

E-062

EDDP-D3 perchlorate solution, 1.0 mg/mL in methanol (as pyrrolinium), ampule of 1 mL, certified reference material, Cerilliant®

M-008

(±)-Methadone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-019

(±)-Methadone solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-021

(±)-Methadone-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-088

(±)-Methadone-D9 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-089

(±)-Methadone-D9 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Karen Marie Dollerup Holm et al.
Journal of analytical toxicology, 36(7), 487-496 (2012-07-11)
We developed a method based on liquid chromatography coupled with tandem mass spectrometry to quantify individual enantiomers of methadone and its primary metabolite, R/S-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium (EDDP), in postmortem blood and brain tissue. Samples were prepared with a Tecan Evo robotic system.
Mei-Han Huang et al.
Toxicology, 280(1-2), 1-9 (2010-11-26)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline)
Mathew George et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 8(4), 432-435 (2012-08-18)
Reports describing methadone overdose in adult and pediatric patient populations are not uncommon. Reports in the preterm neonate patient population, however, are infrequent even though the utilization of methadone in that population continues to increase. Significant age-related pharmacokinetic differences complicate
Teresa R Gray et al.
Forensic science international, 206(1-3), 98-102 (2010-07-30)
Oral fluid testing is widely used for detecting drug exposure, but data describing methadone and metabolites in oral fluid during pharmacotherapy for opioid-dependence are relatively limited. 414 oral fluid specimens from 16 opioid-dependent pregnant women receiving daily methadone were analyzed
Wenjie Jessie Lu et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(8), 1308-1313 (2010-04-23)
The peripheral conversion of testosterone to estradiol by aromatase is the primary source of endogenous estrogen in postmenopausal women. Studies indicating that placental aromatase is able to metabolize methadone to its primary metabolite, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidin (EDDP), led us to
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