850459C

16:0-20:4 PC

Avanti Research^™ - A Croda Brand

• Synonym(s): 1-hexadecanoyl-2--(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4(5Z,8Z,11Z,14Z))
• Empirical Formula (Hill Notation): C₄₄H₈₀NO₈P
• CAS Number: 35418-58-7
• Molecular Weight: 782.08
• UNSPSC Code: 51191904
• NACRES: NA.25

Properties

• description: 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine, chloroform
• Assay: >99% (TLC)
• form: liquid
• packaging: pkg of 1 × 2.5 mL (850459C-25mg); pkg of 2 × 4 mL (850459C-200mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• concentration: 10 mg/mL (850459C-25mg); 25 mg/mL (850459C-200mg)
• lipid type: cardiolipins; phospholipids
• shipped in: dry ice
• storage temp.: −20°C
• InChI: 1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-21-22-23-25-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-24-19-17-15-13-11-9-7-2/h14,16,20-21,23,25,28,30,42H,6-13,15,17-19,22,24,26-27,29,31-41H2,1-5H3/b16-14-,21-20-,25-23-,30-28-/t42-/m1/s1
• InChI key: PUDHBQQGURLBGJ-IVFHWKNFSA-N

Description

General description

Phosphatidylcholine (PC) is one of the major glycerophospholipids of the eukaryotic membranes. PC is zwitterionic. PC is synthesized via two pathways in higher eukaryotes like the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway.

Application

16:0-20:4 PC is suitable for use:

• in the preparation of auto-oxidised phospholipid for electrospray ionisation mass spectroscopic (ESI-MS) analysis
• in liposome preparation for the treatment of organoid
• as antigen in enzyme linked immunosorbent assay (ELISA) for the detection of autoantibodies to phospholipids

Biochem/physiol Actions

Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. PC is the dominant phospholipid present in cancer and neo-neoplastic tissues. Level of 16:0-20:4 PC is less in multiple myeloma cells than in normal plasma cells.

Packaging

5 mL Clear Glass Sealed Ampule (850459C-200mg)

5 mL Clear Glass Sealed Ampule (850459C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• Precautionary Statements: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Target Organs: Central nervous system, Liver,Kidney
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash