SML1954

X-34

≥90% (HPLC), powder, amyloid-specific fluorescent dye

• Synonym(s): 1,4-Bis(3-carboxy-4-hydroxyphenylethenyl)benzene
• Empirical Formula (Hill Notation): C₂₄H₁₈O₆
• CAS Number: 215294-98-7
• Molecular Weight: 402.40
• MDL number: MFCD30474509
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: X-34, ≥90% (HPLC)
• Quality Level: 100
• Assay: ≥90% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2.0 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC(C=C1)=C(C(O)=O)C=C1C=CC2=CC=C(C=CC3=CC=C(O)C(C(O)=O)=C3)C=C2
• InChI: 1S/C24H18O6/c25-21-11-9-17(13-19(21)23(27)28)7-5-15-1-2-16(4-3-15)6-8-18-10-12-22(26)20(14-18)24(29)30/h1-14,25-26H,(H,27,28)(H,29,30)
• InChI key: MCBNOAYTZBUCSX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Fluorescent, amyloid-specific dye

X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimer′s disease (AD).

X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable