Arsenic(III) oxide is soluble in a 1 M aqueous solution of sodium hydroxide (NaOH) up to a concentration of 66 mg/mL. To prepare a 1 M NaOH solution, slowly add 39.997 grams of solid NaOH to approximately 800 mL of water with stirring, then carefully dilute the volume to 1 liter with water. Dissolving NaOH in water is a highly exothermic process, as is the dilution of a concentrated NaOH solution, so the process should be carried out slowly to avoid boiling. Each milliliter of this alkaline solution can dissolve up to 66 milligrams of arsenic(III) trioxide.
A1010
Arsenic(III) oxide
ReagentPlus®, ≥99.0%
Synonym(s):
Arsenic trioxide, Arsenous acid
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About This Item
Empirical Formula (Hill Notation):
As2O3
CAS Number:
Molecular Weight:
197.84
EC Number:
MDL number:
UNSPSC Code:
12171602
PubChem Substance ID:
NACRES:
NA.55
Assay:
≥99.0%
form:
powder
Pricing and availability is not currently available.
Recommended Products
vapor pressure
0 hPa ( 66 °C)
Quality Level
product line
ReagentPlus®
Assay
≥99.0%
form
powder
storage temp.
room temp
SMILES string
O=[As]O[As]=O
InChI
1S/As2O3/c3-1-5-2-4
InChI key
IKWTVSLWAPBBKU-UHFFFAOYSA-N
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General description
Arsenic(III) oxide, also known as arsenic trioxide, is an amphoteric oxide that serves as a raw material for the synthesis of several arsenic-based compounds. It is utilized to decolorize glasses and enamels.[1] Its efficacy in treating in acute promyelocytic leukaemia (APL) has been investigated.[2][3][4]
Application
Arsenic(III) oxide was used in a study detailing the effect of arsenic trioxide in combination with γ-irradiation to elucidate the hemoglobin (Hb).[5]
Biochem/physiol Actions
Very potent agent against acute promyelocytic leukemia (APL). Causes skin, lung and bladder cancer.
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1
Target Organs
Respiratory system,Cardio-vascular system,Gastrointestinal tract
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Wilson H Miller et al.
Cancer research, 62(14), 3893-3903 (2002-07-19)
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations
Combined effect of arsenic trioxide and radiation on physical properties of hemoglobin biopolymer.
Saad-El-Din AA, et al.
Journal of Radiation Research and Applied Sciences, 7(2), 411-416 (2014)
E Lengfelder et al.
Leukemia, 26(3), 433-442 (2011-09-10)
Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological properties of ATO, and summarizes the most relevant results of
Dikshith TSS
Handbook of Chemicals and Safety, 92-92 (1992)
Z X Shen et al.
Blood, 89(9), 3354-3360 (1997-05-01)
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15 APL patients at relapse after all-trans retinoic acid (ATRA) induced and chemotherapy maintained complete remission (CR). As2O3 was administered intravenously at
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How to make a liter of 1M stock solution of As2O3 for experiments if solubility is 66mg/ml in NaOH. Do we have to only dissolve it in NaOH or water is required.
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What is the solution stablity of A1010, Arsenic(III) oxide?
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We do not have any solution stability data for product A1010. Thus it is best to make up fresh solutions of A1010.
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How should product A1010, Arsenic(III) oxide be dissolved?
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This product is soluble in 1 M NaOH at 66 mg/ml, with heat as needed, yielding a clear, colorless solution. This information can be found on the Product Information Sheet.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the difference between Product Nos. A1010 and 202673, Arsenic(III) oxide?
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Both products are Arsenic(III) oxide. The specifications for the products differ. Please see the Specification Sheets for details.
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