44570
Dowtherm® A
eutectic mixture of 26.5% diphenyl + 73.5% diphenyl oxide
Synonym(s):
Diphyl
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About This Item
Recommended Products
Quality Level
refractive index
n20/D 1.590
mp
12-14 °C (lit.)
functional group
phenoxy
phenyl
SMILES string
c1ccc(cc1)-c2ccccc2.O(c3ccccc3)c4ccccc4
InChI
1S/C12H10O.C12H10/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12;1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H;1-10H
InChI key
MHCVCKDNQYMGEX-UHFFFAOYSA-N
General description
Dowtherm® A is a thermally stable organic heat transfer fluid composed of a eutectic mixture of highly stable compounds, biphenyl, and diphenyl oxide. Dowtherm® A is suitable for high-temperature heat transfer applications up to 400 °C. This fluid can be used in both liquid and vapor phase systems.
Application
Dowtherm® A can be used as a high boiling solvent in cyclization reactions. For example, it is used to synthesize:
- 1-Hydroxy-5-methoxy-1,2-dihydrobenzo[f][2,7]naphthyridines from 2-chloro-3-formyl quinolines.
- Isoindolinone derivatives via intramolecular Diels–Alder cycloaddition reactions of substituted pyridazines.
- Phosphorylated azaheterocycles from 2-diethoxyphosphoryl-3-methoxyacrylate via intramolecular cyclizations under thermal conditions.
Legal Information
DOWTHERM is a registered trademark of The Dow Chemical Company or an affiliated company of Dow
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Facile Synthesis of 1-Hydroxy-5-methoxy-Benzo [f][2, 7] naphthyridines
Rajeev PV and Rajendran SP
Synthetic Communications, 40(19), 2837-2843 (2010)
Rolf Winter et al.
Experimental parasitology, 127(2), 545-551 (2010-11-03)
Our prior work on tricyclic acridones combined with a desire to minimize the tricyclic system led to an interest in antimalarial quinolones and a reexamination of endochin, an experimental antimalarial from the 1940's. In the present article, we show that
F M Moh et al.
Journal of AOAC International, 82(4), 893-896 (1999-08-13)
A rapid and direct liquid chromatographic (LC) technique is described for the determination of a eutectic mixture of diphenyl oxide and biphenyl such as Dowtherm A thermal heating fluid (THF) in oleochemicals and palm olein. Analysis is performed with an
Synthesis of isoindolinones via inverse-electron demand Diels-Alder cycloadditions
Huntley RJ, et al.
Tetrahedron Letters, 55(14), 2286-2289 (2014)
F O Dorgelo et al.
International archives of occupational and environmental health, 56(2), 129-134 (1985-01-01)
A study was carried out in a nylon producing plant to determine exposure to Dowtherm A from frequently occurring leaks in the heating system. The daily exposure to both diphenyl and diphenylether of 20 workers was determined over seven consecutive
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