374318
Dimethyl (S)-(−)-malate
98%
Synonym(s):
Dimethyl (S)-2-hydroxysuccinate, Dimethyl L-malate
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About This Item
Linear Formula:
CH3O2CCH2CH(OH)CO2CH3
CAS Number:
Molecular Weight:
162.14
Beilstein:
1724363
EC Number:
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
optical activity
[α]20/D −6.5°, neat
refractive index
n20/D 1.435 (lit.)
density
1.223 g/mL at 25 °C (lit.)
functional group
ester
hydroxyl
storage temp.
2-8°C
SMILES string
COC(=O)C[C@H](O)C(=O)OC
InChI
1S/C6H10O5/c1-10-5(8)3-4(7)6(9)11-2/h4,7H,3H2,1-2H3/t4-/m0/s1
InChI key
YSEKNCXYRGKTBJ-BYPYZUCNSA-N
Application
Dimethyl (S)-(-)-malate may be used as a starting material to synthesize (-)-tulipalin B. The selective reduction of its ester group to alcohol can be accomplished using borane-dimethyl sulfide complex (BMS) in the presence of sodium tetrahydroborate.
This chiral synthon has been used to prepare cytochrome P450 metabolites of arachidonic acid, and cyclic sulfolanes with HIV-1 protease inhibition potential.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Flam. Liq. 3 - Skin Sens. 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
131.0 °F
Flash Point(C)
55 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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A K Ghosh et al.
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Use of enzymic hydrolysis of dimethyl malates for a short synthesis of tulipalin B and of its enantiomer.
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The Journal of Organic Chemistry, 50(7), 1144-1145 (1985)
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