12804

HBTU

≥98.0% (T), for peptide synthesis

• Synonym(s): N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate, O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate
• Empirical Formula (Hill Notation): C₁₁H₁₆F₆N₅OP
• CAS Number: 94790-37-1
• Molecular Weight: 379.24
• Beilstein: 7328329
• EC Number: 423-020-5
• MDL number: MFCD00075445
• UNSPSC Code: 12352107
• PubChem Substance ID: 57647025
• NACRES: NA.22

Properties

• Product Name: HBTU, ≥98.0% (T)
• Quality Level: 200
• Assay: ≥98.0% (T)
• form: solid
• reaction suitability: reaction type: Coupling Reactions
• mp: 200 °C (dec.) (lit.)
• solubility: acetonitrile: 0.1 g/mL, clear
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 2-8°C
• SMILES string: F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C
• InChI: 1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
• InChI key: UQYZFNUUOSSNKT-UHFFFAOYSA-N

Description

General description

HBTU is a peptide coupling agent used in Fmoc-based solid-phase peptide synthesis.

Application

HBTU is a peptide coupling agent for peptide synthesis. It has also been used in standard Fmoc-based solid-phase peptide synthesis (SPPS) protocol.

Recent studies show that crystal as well as solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound; Coupling reagent for peptide synthesis; advantages are: very low racemization, simple reaction conditions, very short reaction time, and high yields.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1A
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves