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T8276

Sigma-Aldrich

Anti-TRPC1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Trpc1 Antibody, Trpc1 Antibody - Anti-TRPC1 antibody produced in rabbit, Anti-Transient receptor potential cation channel, subfamily C, member 1

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About This Item

MDL number:
MFCD02686004
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

immunohistochemistry: suitable
western blot (chemiluminescent): suitable

UniProt accession no.

Q9QX01

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRPC1(7220)
mouse ... Trpc1(22063)
rat ... Trpc1(89821)

General description

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

Immunogen

Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.

Biochem/physiol Actions

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca2+ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

Physical form

Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301 + H311,H411

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2

Supplementary Hazards

EUH032

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Role of Transient Receptor Potential Cation Channel, Subfamily C, Member 1 in the Odontoblast-like Differentiation of Human Dental Pulp Cells
Song Z
Journal of Endodontics, 43, 315-320 (2017)
Jinwang Ye et al.
Aging cell, 19(9), e13209-e13209 (2020-08-21)
Intracellular accumulating of the hyperphosphorylated tau plays a pivotal role in neurodegeneration of Alzheimer disease (AD), but the mechanisms underlying the gradually aggravated tau hyperphosphorylation remain elusive. Here, we show that increasing intracellular tau could upregulate mRNA and protein levels
Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
Chen K
Endocrine Research, 38, 59-68 (2013)
Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing
Selli C
Molecular and Cellular Biochemistry, 420, 129-140 (2016)
Yewei Liu et al.
Frontiers in physiology, 5, 38-38 (2014-02-28)
Satellite cells, as stem cells of adult skeletal muscle, are tightly associated with the differentiated muscle fibers and remain quiescent in the absence of muscle damage. In response to an injury, the quiescent satellite cell is activated by soluble factors
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