K3644

K 858

≥98% (HPLC)

• Synonym(s): K858, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide
• Empirical Formula (Hill Notation): C₁₃H₁₅N₃O₂S
• CAS Number: 72926-24-0
• Molecular Weight: 277.34
• MDL number: MFCD00181155
• UNSPSC Code: 12352202
• PubChem Substance ID: 329817139
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
• InChI: 1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
• InChI key: JEFVYQYZCAVNTP-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable