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K1388

Sigma-Aldrich

KT 5823

≥85% (HPLC), lyophilized powder

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About This Item

Empirical Formula (Hill Notation):
C29H25N3O5
CAS Number:
126643-37-6
Molecular Weight:
495.53
MDL number:
MFCD09878278
UNSPSC Code:
12352200
PubChem Substance ID:
24896206
NACRES:
NA.77

Quality Level

100

Assay

≥85% (HPLC)

form

lyophilized powder

color

white

solubility

ethyl acetate: 5 mg/mL

storage temp.

2-8°C

SMILES string

COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC

InChI

1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1

InChI key

QTYMDECKVKSGSM-YMUMJAELSA-N

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General description

KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na+/I− symporter (NIS) expression.

Application

KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.

Biochem/physiol Actions

Selective inhibitor of PKG.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells.
Burkhardt M, et al.
The Journal of Biological Chemistry, 275(43), 33536-33541 (2000)
Fei Sun et al.
Frontiers in cell and developmental biology, 9, 681421-681421 (2021-07-17)
Sensorineural hearing loss (SNHL) is a dominant public health issue affecting millions of people around the globe, which is correlated with the irreversible deterioration of the hair cells and spiral ganglion neurons (SGNs) within the cochlea. Strategies using bioactive molecules
Junhui Sun et al.
Free radical biology & medicine, 54, 105-112 (2012-09-20)
Nitric oxide (NO) plays an important role in acute ischemic preconditioning (IPC). In addition to activating soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathways, NO-mediated protein S-nitros(yl)ation (SNO) has been recently shown to play an essential
PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells.
Harraz OF, et al.
eLife, 7(6), e38689-e38689 (2018)
A N Meints et al.
Journal of neuroendocrinology, 24(8), 1166-1181 (2012-04-11)
Nitric oxide synthase (NOS) immunoreactivity is present in goldfish gonadotrophs. The present study investigated whether two native goldfish gonadotrophin-releasing hormones (GnRHs), salmon (s)GnRH and chicken (c)GnRH-II, use NOS/nitric oxide (NO) and soluble guanylate cyclase (sGC)/cyclic (c)GMP/protein kinase G (PKG) signalling
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