A6608

Albumin human

recombinant, expressed in Saccharomyces cerevisiae, aqueous solution, 10% in aqueous buffer, ≥99% (agarose gel electrophoresis)

• Synonym(s): rHSA
• Empirical Formula (Hill Notation): C₂₉₃₆H₄₆₂₄N₇₈₆O₈₈₉S₄₁
• CAS Number: 70024-90-7
• Molecular Weight: 66471.53
• MDL number: MFCD00081418
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Properties

• biological source: human
• Quality Level: 200
• recombinant: expressed in Saccharomyces cerevisiae
• Assay: ≥99% (agarose gel electrophoresis)
• form: aqueous solution
• mol wt: monomer ~67 kDa
• concentration: 10% in aqueous buffer
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)C(F)(F)C(F)(F)F
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Description

General description

Albumin constitutes 25% of the proteins produced by the liver[1] and is a prominent protein found in the blood. It is a protein of a single polypeptide chain with a thiol group.[2]

Application

Albumin human has been used:

• to study its adsorption process on model mica surface at pH 3.5 using the atomic force microscopy (AFM) and in situ streaming potential measurements[3]
• to study its proteolytic activities under reducing conditions[4]
• in the medium for stem cell cultivation[5]

This recombinant variant is recommended for use in absorption, distribution, metabolism, and excretion (ADME) pharmacological research; cell culture; drug delivery research; and cryopreservation of cells.

Biochem/physiol Actions

Albumin is a binding and transport protein that serves as a protein repository and a carrier for amino acids. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This also prevents the loss of substance through excretion.[6] Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia.[1] This product can be used in the pharmaceutical industry as a drug excipient and to coat medical devices.[3]

Albumins are soluble monomeric proteins found in the body fluids and tissues of animals and in some plant seeds. Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones. Serum albumins are also vital in regulating the colloidal osmotic pressures of blood.

Analysis Note

Endotoxin tested

Other Notes

View more information on human serum albumin.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable