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917362

Sigma-Aldrich

2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C18H25NO4
CAS Number:
Molecular Weight:
319.40
UNSPSC Code:
12352106
NACRES:
NA.22

Quality Level

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

mp

164-170 °C

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(OC(C)(C)C)N1CCC(C2=CC=C(CC(O)=O)C=C2)CC1

Application

2-(4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Pictograms

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Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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