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8.51006
HBTU
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
Synonym(s):
HBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate
About This Item
Product Name
HBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem®
Quality Level
product line
Novabiochem®
Assay
≥99.0% (HPLC)
form
powder
potency
>2000 mg/kg LD50, oral (Rat)
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
pH
4.1 (1.6 g/L in H2O)
mp
250 °C
solubility
1.6 g/L
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
[N+](=C(N(C)C)O[n]1nnc2c1cccc2)(C)C
InChI
1S/C11H16N5O/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16/h5-8H,1-4H3/q+1
InChI key
CLZISMQKJZCZDN-UHFFFAOYSA-N
General description
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Knorr, et al. (1989) Tetrahedron Lett., 30, 1927.
[2] M. S. Bernatowicz, et al. (1989) Tetrahedron Lett., 30, 4645.
[3] D. Ambrosius, et al. (1989) Biol. Chem. Hoppe-Seyler, 370, 217.
[4] C. G. Fields, et al. (1991) Pept. Res., 4, 95.
[5] A. G. Beck-Sickinger, et al. (1991) Pept. Res., 4, 88.
[6] G. E. Reid, et al. (1992) Anal. Biochem., 200, 301.
[7] G. B. Fields, et al. in ′Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium′, R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
[8] P. A. Baybayan, et al. in ′Peptides, Chemistry & Biology, Proc. 12th American Peptide Symposium′, J. A. Smith & J. E. Rivier (Eds), ESCOM, Leiden, 1992, pp. 566.
[9] J. J. Dudash, et al. (1993) Synth. Commun., 23, 349.
Application
- Synthesis of Quinoxaline Derivatives Using HBTU: A study highlighting the use of HBTU as a Lewis acid catalyst for synthesizing quinoxaline derivatives, presenting a mild and green protocol (Popatkar and Meshram, 2020).
- Efficient Conversion of Carboxylic Acids into Benzimidazoles: Details an HBTU-promoted methodology for converting carboxylic acids into benzimidazoles in a one-pot strategy (Barasa and Yoganathan, 2018).
- Synthesis of Malonyl-linked Glycoconjugates: Discusses the use of HBTU in the synthesis of glycoconjugates, comparing its efficiency with other reagents (Nörrlinger et al., 2016).
Linkage
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1A
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Articles
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
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