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750026

Sigma-Aldrich

3α,5β-Tetrahydroaldosterone

≥98% (CP)

Synonym(s):

11β,18-Epoxy-3α,18,21-trihydroxy-5β-pregnan-20-one, 5β-Pregnan-11β,18-epoxy-3α,18,21-triol-20-one

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About This Item

Empirical Formula (Hill Notation):
C21H32O5
CAS Number:
13489-75-3
Molecular Weight:
364.48
UNSPSC Code:
12352211
PubChem Substance ID:
329766040
NACRES:
NA.24

Quality Level

200

Assay

≥98% (CP)

form

powder

technique(s)

mass spectrometry (MS): suitable

storage temp.

−20°C

SMILES string

C[C@]12CC[C@@H](O)C[C@H]1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@@]45C[C@H](O[C@@H]5O)[C@H]23

InChI

1S/C21H32O5/c1-20-7-6-12(23)8-11(20)2-3-13-14-4-5-15(16(24)10-22)21(14)9-17(18(13)20)26-19(21)25/h11-15,17-19,22-23,25H,2-10H2,1H3/t11-,12-,13+,14+,15-,17+,18-,19+,20+,21-/m1/s1

InChI key

JDEYOKPHRJVBQO-BMDKAXIVSA-N

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Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Precautionary Statements

P280 - P333 + P313

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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B J Koopman et al.
Journal of chromatography, 378(2), 283-292 (1986-06-13)
A newly devised procedure for a simultaneous determination of urinary tetrahydroaldosterone and aldosterone is described. The procedure is based on deconjugation and acetalization, followed by extraction and derivatization of the urinary compounds to their trimethylsilyl ethers and subsequent gas chromatographic-mass
T Miyazaki et al.
Endocrinologia japonica, 36(1), 95-100 (1989-02-01)
Analysis of urinary metabolites of [1, 2-3H]-3 alpha, 5 beta-tetrahydroaldosterone was performed in male guinea-pigs. Separation of urinary metabolites was carried out by means of DEAE-Sephadex A-25 column chromatography and four fractions (fraction A to fraction D) were detected. 46-50%
G T Griffing et al.
Hypertension (Dallas, Tex. : 1979), 7(2), 178-181 (1985-03-01)
19-Nor-deoxycorticosterone (19-nor-DOC) is a human mineralocorticoid. The regulation of its secretion is poorly understood, as renin angiotensin II (ANG II) stimulation has minimal effects on 19-nor-DOC. This study sought to determine if ANG II inhibition would decrease 19-nor-DOC production. Six
B G Wolthers et al.
Clinica chimica acta; international journal of clinical chemistry, 236(1), 33-43 (1995-04-30)
A case is described of a newborn, admitted to hospital because of severe salt loss at the age of 1 month. Subsequent analysis of urinary steroid excretion, by gas chromatography and gas chromatography-mass spectrometry, revealed that the patient suffered from
S Ulick et al.
The Journal of clinical endocrinology and metabolism, 76(4), 873-878 (1993-04-01)
18-Hydroxycortisol and 18-oxocortisol have been isolated from the urine of patients with aldosterone producing adrenocortical adenomas, but not from those with idiopathic hyperaldosteronism associated with bilateral adrenal hyperplasia. These C-18 oxygenated cortisols are biosynthesized by the substitution of cortisol for
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