SRP6518

Plasminogen from human plasma

≥95% (SDS-PAGE)

• Sinónimos: PLG
• Código UNSPSC: 12352202
• NACRES: NA.32

Propiedades

• origen biológico: human
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: lyophilized
• mol peso: 90.0 – 92.0 kDa
• envase: pkg of 1 mg
• Nº de acceso UniProt: P00747
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... PLG(5340)

Descripción

Descripción general

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

Acciones bioquímicas o fisiológicas

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Forma física

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable