SML3213

Lobaplatin

≥98% (NMR)

• Sinónimos: Cis-[trans-1,2-cyclobutanebis(methylamine)-N,N′]-[(2S)-lactate-O1,O2)-platinum (II), D 19466, D-19466, D19466, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum, trans-1,2-Cyclobutanedimethanamine, platinum complex
• Fórmula empírica (notación de Hill): C₉H₁₈N₂O₃Pt
• Número de CAS: 135558-11-1
• Peso molecular: 397.33
• Código UNSPSC: 12352107
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (NMR)
• Formulario: powder
• color: white to beige
• solubilidad: H₂O: 2 mg/mL, clear (Warmed)
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C1[O-][Pt+2]2(N[CH2]C3CCC3CN2)[O-]C1C
• InChI: 1S/C6H12N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-8H,1-4H2;2H,1H3,(H,5,6);/q-2;-1;+4/p-1/t;2-;/m.0./s1
• Clave InChI: HADHSETVEMCBPU-TYOUJGAFSA-M

Descripción

Acciones bioquímicas o fisiológicas

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

Third-generation platinum anticancer agent in vitro and in vivo.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable