SML1890

MK204

≥98% (HPLC)

• Sinónimos: 2-[5-Chloro-2-[[[(2,3,4,5,6-pentabromophenyl)methyl]amino]carbonyl]phenoxy]-acetic acid
• Fórmula empírica (notación de Hill): C₁₆H₉Br₅ClNO₄
• Número de CAS: 1959605-73-2
• Peso molecular: 714.22
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 3 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(C1=C(OCC(O)=O)C=C(C=C1)Cl)NCC(C(Br)=C(C(Br)=C2Br)Br)=C2Br
• InChI: 1S/C16H9Br5ClNO4/c17-11-8(12(18)14(20)15(21)13(11)19)4-23-16(26)7-2-1-6(22)3-9(7)27-5-10(24)25/h1-3H,4-5H2,(H,23,26)(H,24,25)
• Clave InChI: QYSFXUVFRUYJCZ-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10).

MK204 is a potent and selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10). AKR1B10 is induced in several cancer types, in particular, hepatocellular carcinoma, and may be involved with drug resistance. MK204 appears to target a distinct AKR1B10 inner specificity pocket not present in the closely related aldose reductase. MK204 had an IC₅₀ value of 80 nM compared to an IC₅₀ value of 21.7 μM for aldose reductase.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable