SML0772

Curvularin

from Penicillium citrinum, ≥98% (HPLC)

• Sinónimos: 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-,(4S)-
• Fórmula empírica (notación de Hill): C₁₆H₂₀O₅
• Número de CAS: 10140-70-2
• Peso molecular: 292.33
• Número MDL: MFCD09752718
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329825596
• NACRES: NA.77

Propiedades

• origen biológico: Penicillium citrinum
• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: DMSO: 1 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: OC1=C(C(CCCCC[C@H](C)O2)=O)C(CC2=O)=CC(O)=C1
• InChI: 1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1
• Clave InChI: VDUIGYAPSXCJFC-JTQLQIEISA-N

Descripción

Acciones bioquímicas o fisiológicas

S - Curvularin is a macrocyclic lactone with cytotoxic activity. Curvularin inhibits cell division as well as expression of human inducible nitric oxide synthase (iNOS), an enzyme critically involved in pro-inflammatory immune processes. Curvularin anti-inflammatory activity was demonstrated in chronic inflammatory disease models in mice such as Chronic Induced Arthritis (CIA) as well as in human alveolar epithelial A549/8 cells.

Curvularin is a macrocyclic lactone with cytotoxic activity.

Reconstitución

Soluble in DMSO (1 mg/mL), Chloroform (3 mg/mL) and Dichloromethane (3 mg/mL). Note: Insoluble in water.

Otras notas

Store the product sealed at −20 °C. Under these conditions the product is stable for at least 5 years.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H302
• Clasificaciones de peligro: Acute Tox. 4 Oral
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable