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R0283

Sigma-Aldrich

Ropivacaine hydrochloride monohydrate

≥98% (HPLC)

Sinónimos:

(2S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide hydrochloride monohydrate, (S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate, Naropin hydrochloride monohydrate

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About This Item

Fórmula empírica (notación de Hill):
C17H26N2O · HCl · H2O
Número de CAS:
132112-35-7
Peso molecular:
328.88
MDL number:
MFCD00946578
UNSPSC Code:
12352203
PubChem Substance ID:
329823983
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -9 to -12, c = 1 in methanol

storage condition

desiccated

color

white to off-white

solubility

H2O: 5 mg/mL, clear

originator

AstraZeneca

storage temp.

2-8°C

SMILES string

O.Cl.CCCN1CCCC[C@H]1C(=O)Nc2c(C)cccc2C

InChI

1S/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2/t15-;;/m0../s1

InChI key

VSHFRHVKMYGBJL-CKUXDGONSA-N

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General description

Ropivacaine has lidocaine-related structure with tertiary amine side chains. It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom.

Application

Ropivacaine hydrochloride monohydrate has been used as an analyte in tandem mass spectrometry and as an amide-based local anaesthetic to test its effect on breast cancer cell methylation.

Biochem/physiol Actions

Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers.
Ropivacaine less lipophilic as compared with bupivacaine. It is metabolized in the liver by the enzyme cytochrome P4501A2. Ropivacaine elicits less central nervous system (CNS) toxicity and is used as a local anaesthetic during postoperative and labour pain.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000210680
0000210681
114M4746V
063M4706V

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Bupivacaine hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1078507

Bupivacaine hydrochloride

USP

USP

1605512

Ropivacaine Related Compound A

Lidocaine powder

Sigma-Aldrich

L7757

Lidocaine

Yuzhuo Wang et al.
International journal of cancer, 142(8), 1602-1610 (2017-12-02)
Traditional pathway analysis map single nucleotide polymorphisms (SNPs) to genes according to physical position, which lacks sufficient biological bases. Here, we incorporated genetics of gene expression into gene- and pathway-based analysis to identify genes and pathways associated with lung cancer
Jian Zhang et al.
Scientific reports, 8(1), 14181-14181 (2018-09-23)
The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population. Additionally, we also attempted to identify whether there is an association between Dvl3 variants and
Janson J White et al.
American journal of human genetics, 98(3), 553-561 (2016-03-01)
Robinow syndrome is a rare congenital disorder characterized by mesomelic limb shortening, genital hypoplasia, and distinctive facial features. Recent reports have identified, in individuals with dominant Robinow syndrome, a specific type of variant characterized by being uniformly located in the
P Lirk et al.
British journal of anaesthesia, 113 Suppl 1, i32-i38 (2014-06-21)
Lidocaine demethylates deoxyribonucleic acid (DNA) in breast cancer cells. This modification of epigenetic information may be of therapeutic relevance in the perioperative period, because a decrease in methylation can reactivate tumour suppressor genes and inhibit tumour growth. The objectives of
Gaurav Kuthiala et al.
Indian journal of anaesthesia, 55(2), 104-110 (2011-06-30)
Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics via reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and
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