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Merck

GW20083F

Sigma-Aldrich

Anti-Human IgG (Fc specific) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Immunoglobulin G Fc

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

origen biológico

chicken

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

rat, human, mouse

fabricante / nombre comercial

Genway 15-288-20083F

técnicas

western blot: suitable

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... IGHG1(3500)

Inmunógeno

IgG Fc human native protein.

Aplicación

Anti-Human IgG (Fc specific) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Acciones bioquímicas o fisiológicas

Ig γ-1 chain C region is a protein encoded by the IGHG1 gene in humans. Igγ-1 chain C region is present in human pancreatic cancer tissues and its expression is very low in adjacent noncancerous tissues. IGHG1 blockage leads to retarded tumor growth and improved survival. Its presence in pancreatic cancer cells might constitute an important element that is responsible for tumor cell proliferation and immune evasion mechanisms. IGHG1 is associated with prostate cancer and can inhibit cell viability leading to apoptosis. It may act as a potential target in prostate cancer gene therapy.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Judith Blaine
Methods in molecular biology (Clifton, N.J.), 2224, 123-132 (2021-02-20)
Proteinuria is a widely used marker of renal disease and is strongly associated with renal and cardiovascular outcomes. The molecular mechanisms underlying filtration of serum proteins through the glomerular filtration barrier (GFB) remain to be determined. Since the GFB is
Bin Pan et al.
Molecular biology reports, 40(1), 27-33 (2012-11-03)
To investigate the immunoglobulin G (IgG) expression in prostate cancer cell lines and explore the effects of IGHG1 gene knockdown on PC3 cell growth and apoptosis. Flow cytometry, qPCR and western blot were used to demonstrate IgG expression in prostate
Xiaoyan Li et al.
Pancreas, 40(5), 753-761 (2011-06-10)
To investigate the expression of Igγ-1 chain C region (IGHG1) in human pancreatic carcinomas and determine the biological function of IGHG1 expression in immune evasion mechanisms. Comparative proteomic analysis was used to detect the differential expression of IGHG1 in human
James Dylewski et al.
PloS one, 14(2), e0209732-e0209732 (2019-02-28)
Proteinuria is strongly associated with kidney disease progression but the mechanisms underlying podocyte handling of serum proteins such as albumin and IgG remain to be elucidated. We have previously shown that albumin and IgG are transcytosed by podocytes in vitro.

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