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G5035

Sigma-Aldrich

Granulocyte-Macrophage Colony-Stimulating Factor human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

GM-CSF human

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About This Item

Número MDL:
MFCD00166611
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Granulocyte-Macrophage Colony-Stimulating Factor human, GM-CSF, recombinant, expressed in E. coli, suitable for cell culture

origen biológico

human

Nivel de calidad

200

recombinante

expressed in E. coli

Ensayo

≥98% (SDS-PAGE)

Formulario

lyophilized powder

potencia

≤0.1 ng/mL EC50

mol peso

14.6 kDa

envase

pkg of 4X5 μg
pkg of 5 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

≤1.000 EU/μg

color

white

solubilidad

water: soluble 0.010 mL, clear, colorless

Nº de acceso UniProt

P04141

temp. de almacenamiento

−20°C

Información sobre el gen

human ... CSF2(1437) , CSF2(1437)

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Descripción general

Package size based on protein content

Acciones bioquímicas o fisiológicas

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth and differentiation factor for cells in the granulocyte, macrophage and eosinophil lineage. GM-CSF stimulates colony formation from pluripotential progenitor cells at extremely low concentrations and is an essential survival and proliferative factor for hematopoietic progenitor cells in all divisions up to maturity. It also stimulates growth in some epithelial cells and osteoclasts. GM-CSF is produced by a variety of cell types (monocytes, endothelial cells, T-cells, fibroblasts, mitogen-stimulated B-cells, and LPS-stimulated macrophages). GM-CSF is secreted as a single chain glycoprotein containing 128 amino acids for human with a conserved disulfide bond. Human and murine GM-CSF share approx. 54% sequence homology and do not cross-react in bioactivity.

Forma física

Lyophilized from a 0.2 μm filtered, 10 mM sodium citrate, pH 3.5 solution.

Nota de análisis

The proliferative activity of human GM-CSF is tested in culture using human TF-1 cells.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000416949
0000416949
0000321537
0000215784
049M4181V

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