C4520

Cephalothin sodium salt

• Sinónimos: 7-(2-Thienylacetamido)cephalosporanic acid sodium salt, Cephalotin sodium salt
• Fórmula empírica (notación de Hill): C₁₆H₁₅N₂NaO₆S₂
• Número de CAS: 58-71-9
• Peso molecular: 418.42
• Beilstein/REAXYS Number: 4120706
• EC Number: 200-394-6
• MDL number: MFCD00072025
• UNSPSC Code: 51282506
• PubChem Substance ID: 24278314
• NACRES: NA.85

Propiedades

• form: crystalline powder
• Quality Level: 200
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [Na+].CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C([O-])=O
• InChI: 1S/C16H16N2O6S2.Na/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10;/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23);/q;+1/p-1/t12-,15-;/m1./s1
• InChI key: VUFGUVLLDPOSBC-XRZFDKQNSA-M

Descripción

General description

Chemical structure: ß-lactam

Application

Cephalothin is a first-generation cephalosporin antibiotic used to study the mechanism of liposome encapsulated antibiotics, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics, and for immunology studies in relation to antibiotics. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Mode of Action: Disrupts the synthesis of the peptidoglycan layer of bacterial cell walls.

Antimicrobial spectrum: Effective aginast both Gram-positive and Gram-negative bacteria.

Mode of Resistance: Production of cephalosporinase will inactivate the product.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Información de seguridad

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves