PHR1121
2-Phenoxyethanol
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Ethylene glycol monophenyl ether, Phenylglycol
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About This Item
Fórmula lineal:
C6H5OCH2CH2OH
Número de CAS:
Peso molecular:
138.16
Beilstein:
1364011
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
Productos recomendados
grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
Agency
traceable to Ph. Eur. P0950000
traceable to USP 1526200
familia API
phenoxyethanol
CofA
current certificate can be downloaded
técnicas
HPLC: suitable
gas chromatography (GC): suitable
bp
244-246 °C
mp
11-13 °C
densidad
1.107 g/mL at 20 °C (lit.)
aplicaciones
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
2-30°C
cadena SMILES
OCCOc1ccccc1
InChI
1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2
Clave InChI
QCDWFXQBSFUVSP-UHFFFAOYSA-N
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Descripción general
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions.
Aplicación
The pharmaceutical secondary standard can also be used as follows:
- To determine phenoxyethanol and its major metabolite, phenoxyacetic acid by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma, urine, and 7 different tissue samples
- Development of a reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method to quantify 2-phenoxyethanol from commercially available human vaccines
- Screening of cosmetic products (CPs) for 17 widely used preservatives by high-performance liquid chromatography-photodiode-array-electrospray ionization-mass spectrometry (HPLC-PDA-ESI/MS)
- Thin layer chromatography (TLC)-densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in cream samples
- Analysis of eight volatile and semi-volatile ingredients in a topical formulation by gas chromatography (GC) coupled with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Nota al pie de página
To see an example of a Certificate of Analysis for this material enter LRAC2814 in the slot below. This is an example certificate only and may not be the lot that you receive.
Productos recomendados
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Cláusula de descargo de responsabilidad
The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3
Órganos de actuación
Respiratory system
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
258.8 °F - closed cup
Punto de inflamabilidad (°C)
126 °C - closed cup
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Certificados de análisis (COA)
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Simultaneous densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in creams
Widiretani D, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 26, 37-42 (2013)
Santosh K Tripathi et al.
Organic & biomolecular chemistry, 9(2), 581-587 (2010-11-05)
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good
Jessica Stahl et al.
International wound journal, 7(1), 62-69 (2010-04-23)
A combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) is a commonly used disinfectant in human medicine. As porcine skin represents an adequate model for human skin, the effect of octenidine dihydrochloride and phenoxyethanol on wound healing is studied
Qinghao Zhang et al.
Biochimica et biophysica acta, 1841(7), 934-943 (2014-04-01)
Biosynthesis in vertebrates of long-chain polyunsaturated fatty acids (LC-PUFA) such as arachidonic (ARA; 20:4n-6), eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids requires the catalysis by fatty acyl desaturases (Fads). A vertebrate Fad with Δ4 activity catalyzing the direct conversion
J Scognamiglio et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50 Suppl 2, S244-S255 (2011-11-01)
A toxicologic and dermatologic review of 2-phenoxyethanol when used as a fragrance ingredient is presented. 2-Phenoxyethanol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a primary alcohol. The AAAs are a structurally diverse class of
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