654256-M

TNF-α Inhibitor

The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

• Sinónimos: TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor, 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl
• Fórmula empírica (notación de Hill): C₃₂H₃₂F₃N₃O₂ · 2HCl · 0.5H₂O
• Número de CAS: 1049741-03-8
• Peso molecular: 629.54
• Número MDL: MFCD09265259
• Código UNSPSC: 51111800

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubilidad: DMSO: 10 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: FC(F)(F)c1cc(ccc1)[n]2c3c(c(c2)CN(CCN(Cc4[c](c5c([o]c4)cc(c(c5)C)C)=O)C)C)cccc3.Cl.Cl
• InChI: 1S/C32H32F3N3O2.2ClH/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35;;/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3;2*1H
• Clave InChI: GOZMBJCYMQQACI-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC₅₀ = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC₅₀ = 4.6 µM).

Acciones bioquímicas o fisiológicas

Primary Target
TNF-α

Target IC₅₀: 22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

He, M.M., et al. 2005. Science310, 1022.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable