565749

β-Secretase Inhibitor II

The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Sinónimos: β-Secretase Inhibitor II, Z-VLL-CHO, N-Benzyloxycarbonyl-Val-Leu-leucinal
• Fórmula empírica (notación de Hill): C₂₅H₃₉N₃O₅
• Número de CAS: 263563-09-3
• Peso molecular: 461.59
• Número MDL: MFCD03453567
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 5 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: N([C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C=O)C(=O)OCc1ccccc1
• InChI: 1S/C25H39N3O5/c1-16(2)12-20(14-29)26-23(30)21(13-17(3)4)27-24(31)22(18(5)6)28-25(32)33-15-19-10-8-7-9-11-19/h7-11,14,16-18,20-22H,12-13,15H2,1-6H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1
• Clave InChI: YHUAFMGVVANYBT-FKBYEOEOSA-N

Descripción

Descripción general

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβ_total (IC₅₀ = 700 nM) and Aβ_1-42 (IC₅₀ = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
β-secretase

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Z-Val-Leu-Leu-CHO

Reconstitución

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable