208724

Calpain Inhibitor IV

The Calpain Inhibitor IV controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: Calpain Inhibitor IV, Z-LLY-FMK
• Fórmula empírica (notación de Hill): C₃₀H₄₀FN₃O₆
• Peso molecular: 557.65
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated
• color: white to pale yellow
• solubilidad: DMSO: 25 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A potent, cell-permeable and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M^-1s^-1). Also acts as an inhibitor of cathepsin L (k₂ = 680,000 M^-1s^-1).

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
calpain 2

Product does not compete with ATP.

Reversible: no

k₂ = 28,900 M⁻¹s⁻¹ in the inhibition of calpain II; k2 = 680,000 M⁻¹s⁻¹ in the inhibition of cathepsin L

Advertencia

Toxicity: Standard Handling (A)

Secuencia

Z-Leu-Leu-Tyr-CH₂F

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Nota de análisis

single spot by TLC

Otras notas

Dutt, P., et al. 1998. FEBS Lett. 436, 367.
Angliker, H., et al. 1992. J. Med. Chem. 35, 216.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable