D-048
N-Desmethylclozapine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Fórmula empírica (notación de Hill):
C17H17ClN4
Número de CAS:
Peso molecular:
312.80
EC Number:
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
Productos recomendados
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
shipped in
wet ice
storage temp.
−20°C
SMILES string
Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4
InChI
1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key
JNNOSTQEZICQQP-UHFFFAOYSA-N
General description
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril® and FrazaClo in the US. This Certified Snap-N-Spike® Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS.
Application
- Pharmacokinetic analysis of clozapine and N-Desmethylclozapine: A study conducted by Mach et al. (2024) analyzed clinical and pharmacological factors that influence serum levels of clozapine and its metabolite N-Desmethylclozapine, offering insights into dosing strategies and metabolic pathways relevant to schizophrenia treatment (Mach et al., 2024).
- Chromatographic profiling for clozapine and its metabolites: Hrichi et al. (2024) reviewed chromatographic methods for analyzing antipsychotic drugs, including clozapine and N-Desmethylclozapine, to improve the accuracy of pharmacokinetic studies and enhance drug monitoring capabilities (Hrichi et al., 2024).
- Influence of lifestyle factors on clozapine metabolism: Research by Flanagan et al. (2024) explored the impact of coffee and chocolate ingestion on the plasma concentrations of clozapine and its metabolite N-Desmethylclozapine, providing data crucial for understanding how dietary habits affect antipsychotic drug levels (Flanagan et al., 2024).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Clozaril is a registered trademark of Sandoz, Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Referencia del producto
Descripción
Precios
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
Storage Class
3 - Flammable liquids
wgk_germany
WGK 1
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
R J Flanagan et al.
Forensic science international, 206(1-3), e31-e36 (2010-08-20)
To highlight some problems that may occur when investigating clozapine-associated deaths including (i) that death may be related to gastrointestinal hypomotility and (ii) that post-mortem blood clozapine and norclozapine concentrations may not reflect ante-mortem concentrations. A 41-year-old male died 40
Thomas I F H Cremers et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1909-1916 (2012-06-28)
A significant barrier to realization of the full potential of clozapine as a therapeutic agent in the treatment of schizophrenia is the substantial interpatient variability that exists along the therapeutic continuum of no response-efficacious response-adverse response. Genetic polymorphisms that manifest
Tania Godoy et al.
European journal of oral sciences, 119(4), 275-281 (2011-07-06)
Many drugs (e.g. amisulpride) have been used to treat troublesome clozapine-induced salivation; however, varying success has been achieved in this respect, probably because, until recently, the salivatory action of clozapine has been largely unexplained. In the rat, clozapine and its
Jelveh Lameh et al.
Pharmacology & therapeutics, 115(2), 223-231 (2007-06-23)
Currently available treatments for schizophrenia have limited efficacy and are generally poorly tolerated. However, among these antipsychotic agents, clozapine stands apart in having generally superior motoric tolerability and efficacy. One intriguing possibility, based on clinical correlations, receptor activity profiles and
K Koda et al.
British journal of pharmacology, 162(3), 763-772 (2010-10-21)
We have previously reported that galantamine, a weak acetylcholinesterase inhibitor, improves prepulse inhibition (PPI) deficits in mice reared in social isolation. ACh receptors are involved in the underlying mechanism of PPI, but whether rearing in social isolation causes dysfunction of
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico