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D-033

Supelco

Dihydromorphine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C17H21NO3
Número de CAS:
509-60-4
Peso molecular:
287.35
Número CE:
200-659-6
Número MDL:
MFCD00190622
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329798599
NACRES:
NA.24

grado

certified reference material

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

forensics and toxicology

Formato

single component solution

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

cadena SMILES

O[C@@H](CC1)[C@@]2([H])[C@@]3([C@]1([H])[C@H](N(C)CC3)C4)C5=C4C=CC(O)=C5O2

InChI

1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1

Clave InChI

IJVCSMSMFSCRME-KBQPJGBKSA-N

Descripción general

Dihydromorphine is a semisynthetic opioid analgesic sold under the trade names Paramorfan or Paramorphan for treatment of pain. Dihydromorphine is also a primary active metabolite of the analgesic opioid drug dihydrocodeine. This Snap-N-Spike® Reference Solution is suitable for use as starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from urine drug testing and pain prescription monitoring to pharmaceutical research.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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M Grauert et al.
Journal of medicinal chemistry, 40(18), 2922-2930 (1997-08-29)
We have synthesized a series of stereoisomeric 6,7-benzomorphan derivatives with modified N-substituents and determined their ability to antagonize the N-methyl-D-aspartate (NMDA) receptor-channel complex in vitro and in vivo. The ability of the compounds to displace [3H]-MK-801 from the channel site
G Skopp et al.
Forensic science international, 95(2), 99-107 (1998-09-02)
A report of a fatal dihydrocodeine ingestion under substitution therapy is given. Quantitation of dihydrocodeine, dihydromorphine, N-nordihydrocodeine, dihydrocodeine-6-, dihydromorphine-6- and dihydromorphine-3-glucuronide was performed simultaneously after solid-phase extraction prior to HPLC analysis, and the analytes were detected using their native fluorescence.
Annie-Kim Gilbert et al.
European journal of pharmacology, 492(2-3), 123-130 (2004-06-05)
The present study examined the pharmacology of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin (3,6-diacetyldihydromorphine). Like morphine, dihydromorphine and its acetylated derivatives all were highly selective mu-opioids in receptor binding assays. All the compounds were potent mu-selective analgesics, as shown by their sensitivity
Peter A Crooks et al.
Bioorganic & medicinal chemistry letters, 16(16), 4291-4295 (2006-06-17)
A series of 3-O-acyl-6-O-sulfate esters of morphine, dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate
G B Stefano et al.
Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 113(3), 369-373 (1996-03-01)
A previous report demonstrated the presence of the newly discovered opiate alkaloid selective and opioid peptide insensitive mu3 receptor in ganglia of several invertebrate- and one vertebrate species as well as in microglial cells that had egressed from these ganglia
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