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P63204

Sigma-Aldrich

2,3-Pyridinedicarboxylic acid

99%

Sinónimos:

Quinolinic acid

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About This Item

Fórmula empírica (notación de Hill):
C7H5NO4
Número de CAS:
89-00-9
Peso molecular:
167.12
Beilstein/REAXYS Number:
137110
EC Number:
201-874-8
MDL number:
MFCD00006295
UNSPSC Code:
12352100
PubChem Substance ID:
24278005
NACRES:
NA.22

Quality Level

100

assay

99%

form

powder

mp

188-190 °C (dec.) (lit.)

SMILES string

OC(=O)c1cccnc1C(O)=O

InChI

1S/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)

InChI key

GJAWHXHKYYXBSV-UHFFFAOYSA-N

Gene Information

rat ... Gria1(50592) , Grin2a(24409)

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Categorías relacionadas

Application

Inhibits glucose synthesis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCW5881
WXBD9442V
MKCR9642
MKCP0259
MKCM1590

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L Garcia-Salguero et al.
Archives internationales de physiologie, de biochimie et de biophysique, 99(3), 237-242 (1991-06-01)
The in vitro and in vivo effects of several different inhibitors of carbohydrate metabolism have been studied. The in vitro addition of 5-methoxyindole-2-carboxylic acid (MICA), pent-4-enoic acid, and quinolinic acid to the perfusion medium significantly inhibited liver gluconeogenesis in 48-hour-starved
Dorit Cohen-Carmon et al.
Molecular neurobiology, 57(3), 1768-1777 (2019-12-14)
Huntington's disease (HD) is a neurodegenerative late-onset genetic disorder caused by CAG expansions in the coding region of the Huntingtin (HTT) gene, resulting in a poly-glutamine (polyQ) expanded HTT protein. Considerable efforts have been devoted for studying HD and other
F Moroni et al.
Journal of neurochemistry, 47(6), 1667-1671 (1986-12-01)
Quinolinic acid (QUIN), an excitotoxic tryptophan metabolite, has been identified and measured in human cerebrospinal fluid (CSF) using a mass-fragmentographic method. Furthermore, its content has been evaluated in frontal cortex obtained at autopsy from the cadavers of patients who died
Jessica Huyet et al.
Cell chemical biology, 25(6), 666-676 (2018-03-27)
Phosphoribosyltransferases catalyze the displacement of a PRPP α-1'-pyrophosphate to a nitrogen-containing nucleobase. How they control the balance of substrates/products binding and activities is poorly understood. Here, we investigated the human adenine phosphoribosyltransferase (hAPRT) that produces AMP in the purine salvage
Isabelle M Medana et al.
The Journal of infectious diseases, 185(5), 650-656 (2002-02-28)
A retrospective study of 261 Vietnamese adults with severe malaria was conducted to determine the relationship between cerebrospinal fluid (CSF) levels of metabolites of the kynurenine pathway, the incidence of neurologic complications, and the disease outcome. Three metabolites were measured:
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