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909661

Sigma-Aldrich

d0-DMDSSO crosslinker

≥95%

Sinónimos:

Bis(2,5-dioxopyrrolidin-1-yl) 3,3′-sulfinylbis(2-methylpropanoate), Mass spectrometry-cleavable crosslinker for studying protein-protein interactions

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About This Item

Fórmula empírica (notación de Hill):
C16H20N2O9S
Número de CAS:
1554583-88-8
Peso molecular:
416.40
Código UNSPSC:
12352106

Ensayo

≥95%

Formulario

powder

temp. de almacenamiento

2-8°C

Aplicación

d0-DMDSSO (dimethyl-disuccinimidyl sulfoxide) crosslinker is a homobifunctional, lysine residue-targeting, sulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). d0-DMDSSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines and two symmetrical C-S cleavable bonds adjacent to the central sulfoxide. The post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. d0-DMDSSO crosslinker will also be a useful proteomics tool and aid in the quest for targeting ″undruggable″ protein targets.

Otras notas

Technology Spotlight: Cross-Linkers for Elucidation of Protein-Protein Interactions

Developing New Isotope-Coded Mass Spectrometry-Cleavable Cross-Linkers for Elucidating Protein Structures

Información legal

Subject to US Patent Application #15/275,001 of the Regents of the University of California

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Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Clinton Yu et al.
Analytical chemistry, 86(4), 2099-2106 (2014-01-30)
Structural characterization of protein complexes is essential for the understanding of their function and regulation. However, it remains challenging due to limitations in existing tools. With recent technological improvements, cross-linking mass spectrometry (XL-MS) has become a powerful strategy to define

Artículos

MS-Cleavable Cross-Linkers

Sulfoxide-containing MS-cleavable cross-linkers capture protein-protein interactions in native cellular environments, aiding PPI identification.

MS-Cleavable Cross-Linkers

Sulfoxide-containing MS-cleavable cross-linkers capture protein-protein interactions in native cellular environments, aiding PPI identification.

MS-Cleavable Cross-Linkers

Sulfoxide-containing MS-cleavable cross-linkers capture protein-protein interactions in native cellular environments, aiding PPI identification.

MS-Cleavable Cross-Linkers

Sulfoxide-containing MS-cleavable cross-linkers capture protein-protein interactions in native cellular environments, aiding PPI identification.

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