902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Sinónimos: tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Fórmula empírica (notación de Hill): C₁₉H₃₈O₉
• Número de CAS: 361189-64-2
• Peso molecular: 410.50
• Número MDL: MFCD13185017
• Código UNSPSC: 51171641
• NACRES: NA.22

Propiedades

• Ensayo: ≥95%
• Formulario: liquid
• idoneidad de la reacción: reagent type: cross-linking reagent
• índice de refracción: n/D 1.454
• densidad: 1.068
• grupo funcional: ester; hydroxyl
• temp. de almacenamiento: −20°C
• cadena SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• Clave InChI: VGGDPFAYSOSIOK-UHFFFAOYSA-N

Descripción

Aplicación

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Otras notas

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Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy

Información legal

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable