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Merck

388386

Sigma-Aldrich

4,4′-Methylenebis(cyclohexyl isocyanate), mixture of isomers

90%

Sinónimos:

HMDI, Hydrogenated MDI

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About This Item

Fórmula lineal:
CH2(C6H10NCO)2
Número de CAS:
Peso molecular:
262.35
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Quality Level

assay

90%

form

liquid

refractive index

n20/D 1.497 (lit.)

mp

26 °C (lit.)

density

1.066 g/mL at 25 °C (lit.)

SMILES string

O=C=NC1CCC(CC1)CC2CCC(CC2)N=C=O

InChI

1S/C15H22N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h12-15H,1-9H2

InChI key

KORSJDCBLAPZEQ-UHFFFAOYSA-N

General description

4,4′-Methylenebis(cyclohexyl isocyanate), mixture of isomers (HMDI) is an aromatic diisocyanate with good mechanical properties. It is light stable and is resistant to hydrolysis. It is majorly used in the synthesis of polyurethane.

Application

HMDI forms NCO linkages which can be used in the synthesis of polyurethanes for a variety of biomedical applications.

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Electrospinning of L-tyrosine polyurethanes for potential biomedical applications
Shah PN, et al.
Polymer, 50(10), 2281-2289 (2009)
Hyperbranched polyurethane (HBPU)-urea and HBPU-imide coatings: effect of chain extender and NCO/OH ratio on their properties
Mishra AK, et al.
Progress in Organic Coatings, 74(1), 134-141 (2012)
Biodegradable non-aromatic adhesive polyurethanes based on disaccharides for medical applications
Ates B, et al.
International Journal of Adhesion and Adhesives, 49(10), 90-96 (2014)
M H Karol
Annals of allergy, 66(6), 485-489 (1991-06-01)
Isocyanates are highly reactive chemicals capable of causing a multitude of toxicologic effects including respiratory irritation, dermal irritation, contact sensitivity, and pulmonary hypersensitivity. In order to probe the mechanism(s) underlying these reactions, an animal model has been developed. The guinea
Sanjay Gandhi et al.
American journal of obstetrics and gynecology, 192(5), 1643-1648 (2005-05-20)
The purpose of this study was to examine the histopathologic changes of HMDI (Hexamethylene di-isocyanate) cross-linked porcine dermis grafts used for suburethral sling surgery. Twelve patients underwent reoperation with graft removal for urinary retention or recurrent stress urinary incontinence after

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