254916
7,8-Dihydroxy-6-methoxycoumarin
98%
Sinónimos:
Fraxetin
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About This Item
Fórmula empírica (notación de Hill):
C10H8O5
Número de CAS:
Peso molecular:
208.17
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23
Productos recomendados
Quality Level
assay
98%
form
powder
mp
230-231 °C (lit.)
SMILES string
COc1cc2C=CC(=O)Oc2c(O)c1O
InChI
1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
InChI key
HAVWRBANWNTOJX-UHFFFAOYSA-N
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Joana Terés et al.
Plant, cell & environment, 42(8), 2384-2398 (2019-04-25)
High soil carbonate limits crop performance especially in semiarid or arid climates. To understand how plants adapt to such soils, we explored natural variation in tolerance to soil carbonate in small local populations (demes) of Arabidopsis thaliana growing on soils
Po-Lin Kuo et al.
International immunopharmacology, 6(7), 1167-1175 (2006-05-23)
The survival of osteoblast cells is one of the determinants of the development of osteoporosis in patients with inflamed synovium, such as in rheumatoid arthritis (RA). By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown
Po-Lin Kuo et al.
Biological & pharmaceutical bulletin, 29(1), 119-124 (2006-01-06)
Fraxetin (7,8-dihydroxy-6-methoxy coumarin), a coumarin derivative, was investigated for its effects on differentiation of osteoblasts. By means of alkaline phosphatase (ALP) activity and osteocalcin ELISA assay, we have shown that fraxetin exhibits a significant induction of differentiation in two human
María Isabel Sánchez-Reus et al.
Neuroscience research, 53(1), 48-56 (2005-07-06)
Fraxetin belongs to an extensive group of natural phenolic anti-oxidants. In the present study, using a human neuroblastoma SH-SY5Y cells, we have investigated the protective effects of this compound on modifications in endogenous reduced glutathione (GSH), intracellular oxygen species (ROS)
María Francisca Molina-Jiménez et al.
Toxicology and applied pharmacology, 209(3), 214-225 (2005-05-21)
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. Recently, it has been shown that fraxetin (coumarin) and myricetin (flavonoid) have significant neuroprotective effects against apoptosis induced by rotenone, increase the total glutathione levels in
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