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GW10072F

Sigma-Aldrich

Anti-C-Reactive Protein antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CRP

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-10072F

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CRP(1401)

General description

C-reactive protein (CRP) is a member of a protein family that serve as soluble pattern recognition molecules. This protein is generated and liberated in the circulation in response to infection and tissue damage. CRP gene is located on human chromosome 1q23.2.
CRP is synthesized by human peripheral blood mononuclear cells. The CRP gene is localized to chromosome 1.

Immunogen

C-reactive protein.
Immunogen Sequence: GI # 30213, sequence 1-224

Application

Anti-C-Reactive Protein antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for indirect ELISA.

Biochem/physiol Actions

C-Reactive Protein (CRP) is a homopentamer that belongs to the pentaxin family. CRP binds to phosphorylcholine in a calcium dependent manner and plays a key role in host defense. It is involved in several defense mechanisms such as, agglutination, bacterial capsular swelling, phagocytosis and complement fixation. CRP interacts with secreted M-ficolin anchored to monocyte transmembrane G protein-coupled receptor 43 and mediates immune signaling and regulates host defense. It scavenges nuclear waste that is released from cells following apoptosis.
C-reactive protein (CRP) plays a major role the early stages of atherosclerosis and pantothenic acid (PA). It shows an antioxidant effect in inflammatory process. The active monomeric form of C-reactive protein (CRP) is involved in proinflammatory functions.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The long-term relationship between dietary pantothenic acid (vitamin B5) intake and C-reactive protein concentration in adults aged 40 years and older.
Jung S, et al.
Nutrition, Metabolism, and Cardiovascular Diseases, 27(9), 806-816 (2017)
T M Murphy et al.
The Journal of experimental medicine, 173(2), 495-498 (1991-02-01)
We synthesized and cloned cDNA from human peripheral blood mononuclear cell (PBMC) transcripts that were hybrid selected by pCRP5, a liver C-reactive protein (CRP)-specific cDNA (Woo, P.,J.R. Korenberg, and A.S. Whitehead. 1985. J.Biol. Chem. 260:13384). Three hybrid-selected cDNA clones, HScDNA1
An intrinsically disordered motif mediates diverse actions of monomeric C-reactive protein.
Li HY, et al.
The Journal of Biological Chemistry, 291(16), 8795-8804 (2016)
S Danese et al.
Alimentary pharmacology & therapeutics, 34(1), 1-10 (2011-05-05)
The addition of antitumour necrosis factor-α (TNF-α) agents to the therapeutic armamentarium against Crohn's disease has been a revolution in its management. However, approximately 25 to 40% of patients who initially benefit from anti-TNF-α treatment develop intolerable adverse events or
A P Osmand et al.
Proceedings of the National Academy of Sciences of the United States of America, 74(2), 739-743 (1977-02-01)
Partial amino acid sequences of rabbit C-reactive protein, a peptide derived from human C-reactive protein by cyanogen bromide cleavage, and the C1t subcomponent of the human complement component C1 have been determined. Extensive sequence homology between these proteins establish their

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