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F8190

Sigma-Aldrich

Fucoidan from Fucus vesiculosus

≥95%

Synonym(s):

Fucoidin

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

algae (Fucus Vesiculosus)

Quality Level

Assay

≥95%

form

powder

color

light yellow

useful pH range

5.0-11.0

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

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General description

Fucoidan is a fucose-rich, sulfated polysaccharide isolated from several species of brown seaweed.

Application

Fucoidan from Fucus vesiculosus has been to:
  • study the application of heparin red in detecting fucoidan[1]
  • study its bioactivity as an antimicrobial agent[2]
  • study its effects on advanced glycation end-products[3]

Biochem/physiol Actions

Studies of fucoidan have found it to have a broad variety of biological activities including antitumor and antiangogenic activities, immunomodulatory, anti-inflammatory, anticoagulant, antithrombotic, and antioxidant activities. Fucoidan induces macrophage activation with subsequently activates mitogen activated protein kinases (MAPKs) and results in natural killer cell proliferation. Fucoidan acts as a nonselective selectin blocker and has been shown to induce apoptosis and suppress angiogenesis.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Certificates of Analysis (COA)

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Effects of scavenger receptors-1 class A stimulation on macrophage morphology and highly modified advanced glycation end product-protein phagocytosis
Shinichi H et al.
Scientific Reports, 8(1), 5901-5901 (2018)
Bioactivity of Fucoidan as an Antimicrobial Agent in a New Functional Beverage
Poveda-Castillo et al.
Becker-Shaffer's Diagnosis and Therapy of the Glaucomas (2018)
Fanlu Wang et al.
Marine drugs, 19(4) (2021-04-04)
Fucoidans, sulfated polysaccharides extracted from brown algae, are marine products with the potential to modulate bone formation and vascularization processes. The bioactivity and safety of fucoidans are highly associated with their chemical structure, which may vary with algae species and
Quantification of sulfated polysaccharides in mouse and rat plasma by the Heparin Red mix-and-read fluorescence assay
Ulrich W et al.
ARKIVOC (Gainesville, FL, United States) (2017)
Hang T T Cao et al.
Marine drugs, 16(11) (2018-11-06)
Fucoidans from brown macroalgae have beneficial biomedical properties but their use as pharma products requires homogenous oligomeric products. In this study, the action of five recombinant microbial fucoidan degrading enzymes were evaluated on fucoidans from brown macroalgae: Sargassum mcclurei, Fucus

Questions

  1. CAN YOU PLEASE PROVIDE ME THE FUCOIDAN (FOOD GRADE) COA ??? I DONT HAVE ANY BATCH OR LOT NUMBER OF PRODUCT

    1 answer
    1. This product is not considered Food Grade, it is intended for research use only. Unless otherwise stated this product is intended for research use only and is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. Unfortunately, a Food Grade product option is not currently available.
      Please see the link below to review a sample Certificate of Analysis:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/F8190-500MG0000247167.pdf

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