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5.08438

Sigma-Aldrich

Lamellipodial Growth Promoter, C8N6 BPA Polyamine

Synonym(s):

Lamellipodial Growth Promoter, C8N6 BPA Polyamine, Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine

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About This Item

Empirical Formula (Hill Notation):
C20H48N6 · 6HCl
CAS Number:
Molecular Weight:
591.40
UNSPSC Code:
12352116
NACRES:
NA.77

Assay

≥95% (NMR)

Quality Level

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

water: 100 mg/mL
DMSO: 50 mg/mL

storage temp.

2-8°C

General description

A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~ 10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations. The Cy3 conjugated version is also available (Cat. No. xxxx?)
A cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Nedeva, I., et al. 2013. Nat. Commun.4, 2165.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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